【摘 要】
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The use of CE methods for the separation of chiral compounds has become increasing popular in recent years.Cyclodextrins are the most important chiral selectors used in CE in addition to proteins, cro
【机 构】
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School of Applied Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China
【出 处】
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第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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The use of CE methods for the separation of chiral compounds has become increasing popular in recent years.Cyclodextrins are the most important chiral selectors used in CE in addition to proteins, crown ethers, and macrocyclic antibiotics.In this paper, the separation of the enantiomers of pantoprazole was investigated using charged sulfobutylether-β-cyclodextrin (SBE-β-CD) as chiral selector, and the mechanism of enantioselective recognition was studied.Operation parameters including runnig buffer pH, selector concentration, type and concentration of organic modifiers and applied voltage on the enantioseparation were investigated.An uncoated fused-silica capillary with a total length of 55cm (effective length 38cm) ×50um i.d.was used as the separation channel.
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