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Imidazo[1,2-a]pyrazine analogues as potent Syk inhibitors,in silico methodologies such as molecular docking and three-dimensional quantitative structure–activity relationship modeling were carried out.Two satisfactory models with good predictive abilities have been developed by CoMFA and CoMSIA:CoMFA with cross validated q2,0.737;non-cross-validated r2,0.959;CoMSIA with cross validated q2,0.648;non-cross-validated r2,0.857.