【摘 要】
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Recent chromosome conformation capture(3C)derived techniques have revealed that topologically associating domain(TAD)is a pervasive element in chromatin three-d
【机 构】
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CollegeofInformatics,HuazhongAgriculturalUniversity,Wuhan430070,China
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Recent chromosome conformation capture(3C)derived techniques have revealed that topologically associating domain(TAD)is a pervasive element in chromatin three-dimensional(3D)organization.However,there is currently no parameter to quantitatively measure the structural characteristics of TADs,thus obscuring our understanding on the structural and functional differences among TADs.Here we introduce a theoretical parameter to characterize TAD structures.Applying this defined parameter to 11 Hi-C datasets generated by both traditional and in situ Hi-C experimental pipelines,our analyses reveal that heterogeneous structures exist among TADs,and this structural heterogeneity is significantly correlated to DNA sequences,epigenomic signals and gene expressions.Although TADs can be stable in genomic positions across cell lines,structural comparisons show that a considerable number of stable TADs undergo significantly structural rearrangement during cell changes.Moreover,the structural change of TAD is tightly associated with its transcription remodeling.Altogether,the theoretical parameter provides a quantitative method to link structural characteristics and biological function of TADs,and this linkage implies that chromatin interaction pattern has the potential to mark transcription activity in TADs.
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