【摘 要】
：
2,3-苯并环庚三烯酮(2,3-benzotropone)是环庚三烯酮(tropone)类化合物的一类重要衍生物。作为重要的结构单元,2,3-苯并环庚三烯酮存在于多种具有生物活性的天然产物分子中[1]。其最常用的合成策略为两步,如在苯并环庚酮类化合物的α位引入两个溴原子,进而在碱的作用下消除溴化氢以构建相应的不饱和双键[2]。然而,到目前为止2,3-苯并环庚三烯酮的一步合成法并没有受到应有的重视,
【机 构】
：
南开大学元素有机化学国家重点实验室,天津化学化工协同创新中心,天津市卫津路94号,300071 南
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2,3-苯并环庚三烯酮(2,3-benzotropone)是环庚三烯酮(tropone)类化合物的一类重要衍生物。作为重要的结构单元,2,3-苯并环庚三烯酮存在于多种具有生物活性的天然产物分子中[1]。其最常用的合成策略为两步,如在苯并环庚酮类化合物的α位引入两个溴原子,进而在碱的作用下消除溴化氢以构建相应的不饱和双键[2]。然而,到目前为止2,3-苯并环庚三烯酮的一步合成法并没有受到应有的重视,仅有的几例报道也只局限于特定的反应底物[3]。本文使用高价碘试剂作为氧化剂,可以高效地实现环状1,3-二羰基化合物的双脱氢反应,从而一步合成了2,3-苯并环庚三烯酮类化合物。该方法反应条件温和,操作简便,收率高。
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