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Background: Thefruit of Ziziphus jujubaMill is atraditionalChinese medicine and food.To find optimal Jujube raw material for preparation Jujubefruit oral liquid characterized by the content Cyclic Adenosine Monophosphate(cAMP),four levels Jujubefruitwerechosen.Materials and methods: The cAMP contents of four levels Jujubefruit peels were determined by high performance liquid chromatography.Results: The result showed that the cAMP content of grade A Jujubefruit is lowest and grade D Jujubefruit is highest; what's more,the cAMP content of peel is about 885 μg/g,which is almost eighty percent higher than the pulp's.Conclusion: A new discovery: the highest content cAMP is found in Ziziphus jujuba Mill Peel.