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In the present study,the anticonvulsant effect of BmK IT2,a sodium channel-specific polypeptide purified from the venom of Chinese scorpion Buthus martensi Karsch,has been investigated in experimental epilepsy models of rats.BmK IT2 significantly inhibited pentylenetetrazol-induced generalized seizures in behavior and electroencephalograph (EEG) by unilateral injection into CA1 region of hippocampus.In addition,the latency to status epilepticus onset induced by pilocarpine was prolonged by BmK IT2 pretreatment.Moreover,the hippocampal c-Fos expression during status epilepticus were suppressed by BmK IT2 compared to control.The optimal doses of BmK IT2 were 0.1 2g and 0.5 μg.These results indicate that BmK IT2 has significant anticonvulsant properties on pentylenetetrazol-induced generalized seizures and pilocarpine-induced status epilepticus,providing a potential new antiepileptic drug (AED) in the therapy of epilepsy.