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5. A novel monomethylauristatin E prodrug for malignant cancer targeted therapy

A novel monomethylauristatin E prodrug for malignant cancer targeted therapy

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：shenzhiying

【摘 要】

：

An ideal cancer therapy is to eliminate cancer cells with least damage to normal cells.Monomethyl auristatin E (MMAE),an antimitotic agent inhibiting tubulin polymerization[1],has serve toxicity to tu

【作 者】

：

Shengcai Yang Na Shen Wantong Song Zhaohui Tang Xuesi Chen 

【机 构】

：

Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of S

【出 处】

：

Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

：

2016年11期

【关键词】

：

MMAE drug controlled release cancer-selective prodrug 

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　　An ideal cancer therapy is to eliminate cancer cells with least damage to normal cells.Monomethyl auristatin E (MMAE),an antimitotic agent inhibiting tubulin polymerization[1],has serve toxicity to tumor cells,whereas the great toxicity also limits its clinical application.

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