Development of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：zhaoyouwei119

【摘要】

：

PARP-1 is closely related to the repair of DNA damages caused by Topo inhibitors.The combinations of PARP-1 inhibitor and Topo inhibitor display enhanced antitumor potency and might help to overcome r

【作者】

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Zigao Yuan Shaopeng Chen Changjun Chen Chunmei Gao Yuyang Jiang

【机构】

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The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical

【出处】

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中国化学会第十届全国化学生物学学术会议

【发表日期】

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2017年10期

【关键词】

：

Acridine Amidobenzimidezole PARP Topo Antitumor bioactivity

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Development of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer

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