The prospective study was designed to investigate the clinical and radiographic effects of the new functional intervertebral cervical disc prosthesis in the treatment of patients with single-level and multiple-level degenerative disc disease of the cervical spine.86 patients had spinal arthroplasty with placement of the Bryan cervical artificial disc prosthesis during Dec 2003 to Oct 2010 in our hospital.There were 86 patients who underwent a single-level,two who underwent a two-level and one who underwent a three-level cervical arthroplasty.Clinical (JOA score and Odoms scale.) and radiological (X-ray of anteroposterior ; lateral flexion/extension ; left and right bending position) follow-up was performed.The radiographic parameters evaluated included the treated segments and the overall curvature of the cervical spine.All the patients were followed up from 8 months to 75 months (average 29 months).The JOA score increased from (8.6±1.8) to (15.8±5.4).According to the Odsms scale,all of 76 patients had excellent to good outcome (improvement by at least one grade,73/86 excellent,13/86 good).The ROM recovered to the preoperative value during the follow up (54.3±8.4degrees).The mean preoperative and postoperative ROM of the FSU was 12.3±2.5 and 14.4±2.0 degrees,respectively.The treated segment ultimately showed preservation of movement when compared to preoperative levels.Result from CT or MRI showed position deflexion of the prosthesis metal endplates (<1.5 mm) in 3/86 levels and (1.5~3 mm) in 5/86 levels.No prosthesis subsidence or excursion was identified.Arthroplasty using the Bryan disc appears to be safe and provided a favorable clinical and radiological outcome in our study.While early and intermediate results are promising,long-term follow up studies are required to prove its efficacy and its ability to prevent adjacent segment disease.