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通过检测免疫抑制的Ｆ１小鼠和杂合子Ｆ２裸鼠对Ｆｒｉｅｎｄ小鼠白血病病毒（Ｆｒ．ＭｕＬＶ）感染的敏感性，探讨免疫状态对Ｆｖ－４基因（特别是对Ｆｖ－４基因杂合子）抗ＦｒｉｅｎｄＭｕＬＶ作用的影响。经腹腔接种Ｆｒ．ＭｕＬＶ病毒液攻击小鼠或Ｆ２裸鼠后，检查其脾脏中Ｆｒ．ＭｕＬＶ的增殖及其发病情况。结果表明，免疫抑制的Ｆ１小鼠和杂合子Ｆ１裸鼠都可被Ｆｒ．ＭｕＬＶ感染，脾脏中有病毒增殖；并且，约２／３的杂合子Ｆ２裸鼠与ＢＡＬＢ／Ｃ小鼠一样，在接种病毒后１个月内发病或死亡。说明机体的免疫状态可影响Ｆｖ－４基因，特别是Ｆｖ－４基因杂合子的抗Ｆｒ．ＭｕＬＶ作用。提示在进行基因治疗时要考虑机体的免疫状态等因素。
To investigate the susceptibility of Friend mouse leukemia virus (Fr.MuLV) infection to immunosuppressed F1 mice and heterozygous F2 nude mice and to investigate the effect of immune status on Fv-4 gene (especially Fv-4 gene heterozygote) Effect of FriendMuLV effect. Intraperitoneal inoculation of Fr. After MuLV virus attack on mice or F2 nude mice, Fr in the spleen was examined. MuLV proliferation and its incidence. The results show that immunosuppressed F1 mice and heterozygous F1 nude mice can be Fr. MuLV infection with virus proliferation in the spleen; and about two-thirds of heterozygous F2 nude mice, like BALB / C mice, developed or died within 1 month of inoculation with the virus. Indicating that the immune status of the body can affect Fv-4 gene, in particular Fv-4 gene heterozygous anti-Fr. MuLV effect. Tip gene therapy to consider the body’s immune status and other factors.