EGF-mobilized intracellular calcium of cumulus cells decreases NPR2 affinity for NPPC and induces oo

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：chunmin1986

【摘要】

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【作者】

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Xiaoqiong Hao Yakun Wang Nana Kong Yu Zhang Yu Zhao Guoliang Xia Meijia Zhang

【机构】

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State Key Laboratory for Agrobiotechnology,College of Biological Sciences,China Agricultural Univers

【出处】

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2016年国际生理学学术大会

【发表日期】

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2016年6期

【关键词】

：

Epidermal growth factor Calcium Natriuretic peptide receptor 2 Affinity

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　　Natriuretic peptide type C(NPPC)activation of the guanylyl cyclase-linked natriuretic peptide receptor 2(NPR2)maintains oocyte meiotic arrest.Luteinizing hormone(LH)-dependent epidermal growth factor(EGF)receptor signaling elevates calcium of cumulus cells to inactivate NPR2,resulting in meiotic resumption.

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EGF-mobilized intracellular calcium of cumulus cells decreases NPR2 affinity for NPPC and induces oo

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