苯并咪唑基配合物的合成及其对酪氨酸酶活性抑制的研究

来源 :河南省化学会2016年学术年会 | 被引量 : 0次 | 上传用户：clear0102

【摘要】

：

　　酪氨酸酶是黑色素生物合成的关键限速酶,与自然界生物体的重要生理过程有密切关系[1]。本研究以苯并咪唑基类为配体合成了两个双核的过渡金属配合物,Cd2(p-2-pyb)2(NO3)2

【作者】

：

于淮滨宋巍支双成毛瑞娜张军帅胡继勇赵金安

【机构】

：

郑州大学化学与分子工程学院,河南郑州,450001/河南城建学院材料与化工学院,河南,平顶山467036

【出处】

：

河南省化学会2016年学术年会

【发表日期】

：

2016年8期

【关键词】

：

过渡金属配合物苯并咪唑基酪氨酸酶抑制剂

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论文部分内容阅读

　　酪氨酸酶是黑色素生物合成的关键限速酶,与自然界生物体的重要生理过程有密切关系[1]。本研究以苯并咪唑基类为配体合成了两个双核的过渡金属配合物,Cd2(p-2-pyb)2(NO3)2(1),Zn2(p-2-pyb)2(NO3) 2(2),研究了其对酪氨酸酶二酚酶抑制活力及动力学作用,并深入探究了其对小鼠黑色素瘤 B16 细胞的毒性和黑色素生成量的影响。

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苯并咪唑基配合物的合成及其对酪氨酸酶活性抑制的研究

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