Tactile perception of surfaces is an essential aspect of our daily life and has a profound importance for our well-being. The tactility (rough/smooth, slippery/sticky, comfort, etc.) is perceived by the sliding contact between the fingerpad and the counter-surface, which generates tactile friction to stimulate the cutaneous sensory neurons. Tactile friction can be influenced by the surface topography. In this work, touch perception and tactile friction of four kinds of laser textured surfaces (Groove, Grid, Crater, Hilbert Curve) were studied theoretically and experimentally for the establishment of the correlation between surface texture parameters, tactile friction and tactility. A multi-axis force/torque transducer was used to measure the dyn mic friction between skin and counter-surface in vivo. For the perception experiments, a panel test was conducted and the subjective ratings from 0 to 10 were graded by each participant to describe the level of perceived roughness, perceived stickiness and perceived comfort. The results indicated that: (1) The tactile frictional of anisotropic surface shows dependency on sliding direction, for instance, for groove texture, parallel sliding reveals greater values in coefficient of friction (COF) and a higher dependency of COF on the depth of the grooved channel texture than perpendicular sliding. (2) Comparing to Groove texture and Hilbert Curve texture, Grid texture is the optimal textural design in the concern of friction reduction and orientation effect. (3) Based on the experimental results and skin contact model analysis, the relationship between surface texture parameter and tactile friction is established, which indicated tactile friction can be tailored by changing the surface texture parameters to influence the role of adhesion and/or deformation component of friction. (4) There is a correlation between perceived tactility and tactile friction. From the objective perspective, the dyn mic tactile friction is proved to be an affective physical stimulus which has a negative correlation to the comfort perception. From the subjective perspective, the perceived stickiness is illustrated as a perceptual stimulus which is able to influence the comfort level of perception in a negative correlation. The research provides design tools for texture design of future product surfaces and it is beneficial to understand the tactility related research and product developments in the future.