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Background Drug-eluting stents effectively reduce restenosis but may increase late thrombosis and delayed restenosis.Persistent polymer, the drug, or a combination of both could be responsible.Methods We compared a combo stent (CS), a polymer-free sirolimus-eluting stent coated with anti-CD34 antibody,with a permanent-polymer sirolimus-eluing stent (SES), a polymer-free sirolimus-eluting stent (PFSES) and a bare-metal stent (BMS) at 14 days and 28 days in a porcine model with optical coherence tomography (OCT) and histological analysis.