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Recombinant Newcastle disease virus (rNDV) as oncolytic agent has been shown to be effective for cancer therapy.In this study, we generated recombinant lentogenic NDVs expressing IL-2(rNDV-IL-2), TRAIL (rNDV-TRAIL) or both IL-2 and TRAIL (rNDV-IL-2-TRAIL) at genomic location between HN and L, the parental virus expressing EGFP (rNDV-EGFP) as control.In vitro experiments indicated that these recombinant viruses expressed corresponding gene products, which had been demonstrated biologically active.