Based on the combination of the glycerol aqueous-phase reforming(APR) and catalytic hydrogenation of glycerol, a novel reaction system of liquid phase in-situ hydrogenation of glycerol for the synthesis of 1,3-propanediol is proposed, in which hydrogen is produced from glycerol APR in the same reactor.In the new system, glycerol is the raw material of the APR reaction, the hydrogen generated from the APR of glycerol can simultaneously used as H2 resource for the in-situ hydrogenation of glycerol to produce 1,3-propanediol, which can improve the selectivity of hydrogen for the APR process of glycerol.Thermodynamic calculation of the coupling processes was carried out.