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目的:探讨被动吸烟与宫颈癌、宫颈上皮内瘤变(CIN Ⅰ~Ⅱ)发病的相关性。方法:回顾性研究被确诊并收治的原发性浸润性宫颈癌新发病例192例(宫颈癌组),CIN Ⅰ~Ⅱ 142例(CIN组),正常对照组254例(对照组),进行一对一的问卷调查,运用χ2检验和Logistic回归分析对被动吸烟与宫颈疾病发病的相关性进行分析。结果:无论是距诊断或就诊前近10年内还是10年以前,患病组和对照组是否被动吸烟、被动吸烟的持续时间、接触强度都有显著差别(P<0.01)。Logistic回归分析结果显示10年内被动吸烟时间是宫颈癌和CIN Ⅰ~Ⅱ发病危险因素,分娩次数和肿瘤家族史是CIN Ⅰ~Ⅱ的危险因素,高教育程度和年龄低是保护因素。结论:被动吸烟及接触时间、强度是宫颈疾病发病的相关危险因素。
Objective: To investigate the relationship between passive smoking and cervical cancer and cervical intraepithelial neoplasia (CIN Ⅰ ~ Ⅱ). Methods: A retrospective study of 192 newly diagnosed cases of invasive cervical cancer diagnosed and treated (cervical cancer group), CIN Ⅰ ~ Ⅱ 142 cases (CIN group), 254 cases of normal control group (control group) One-on-one questionnaires, using χ2 test and Logistic regression analysis of passive smoking and cervical disease incidence analysis. Results: No significant difference was found in passive smoking, duration of passive smoking and contact intensity (P <0.01), whether it was within 10 years or 10 years before diagnosis or treatment. Logistic regression analysis showed that passive smoking time was a risk factor for cervical cancer and CIN Ⅰ ~ Ⅱ in 10 years. The number of births and family history of cancer were risk factors of CIN Ⅰ ~ Ⅱ. High educational level and low age were protective factors. Conclusion: Passive smoking and exposure time and intensity are the related risk factors of cervical disease.