I will describe a new topic of research,i.e.,X-ray enabled Nanochemistry.Nanochemistry has generated tremendous impact in both theoretical insight and practical applications because in many cases nanomaterials perform better than the bulk or atomic species.We have recently discovered that nanomaterials may exhibit new properties when they are under X-ray irradiation.These new properties can be used in many applications and deserve much theoretical scrutiny.Several examples of X-ray Enabled Nanochemistry will be given and the future of this new research topic will be discussed.