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Objective Attention-deficit/hyperactivity disorder (AD/HD),characterized by symptoms of inattention and hyperactivity-impulsivity,is a common neurodevelopmental disorder of childhood that often persists into adult life.Since dopamine transporter (DAT)knockout (KO) mice show hyperactivity which can be treated with methylphenidate,DAT-KO mice are considered model mice for AD/HD.However,there have been few studies that focused on postnatal development of DAT-KO mice.We investigated association between postnatal development and methylphenidate induced inhibition of hyperactivity in DAT-KO mice.