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Objective To analyse the characteristics of insulin secretion,blood glucose fluctuation (BGF) and hypoglycemia by observing the insulin release test and blood glucose(BG) profile detected by continuos glucose monitoring system (CGMS) in 20 patients with insulinoma,and to investigate the possible value of CGMS on diagnosis of it.Methods The data of 20 insulinoma patients who had been diagnosed and operated in the First Clinical Hospital of Zhengzhou University from January,2008 to April,2009 were collected.