Since the human genome had been sequenced,the advance of biotechnologies has led to a substantial decrease of the procedure cost from 100 million dollars to 1,000 dollars per individuals genome.Such progress,along with experience,collected in development and research of drugs targeted against genomic and molecular entities,has opened a new era of personalized medicine,which aim is predicting of treatment safety and efficacy in molecularly and genetically defined patients sub-sets and even individual patients.