Background and Purposes: Accumulating evidences implies that the neurotrophic factor and their receptors contribute to tumor progression.GFRα1 is a GPI-anchored receptor for glial cell line-derived ne
Tumors can recruit, induce and expand regulatory T cells (Tregs) to suppress anti-tumor immune responses for survival and progression.The complicated tumor-related Treg subsets and their functional me
Mesenchymal stem cells (MSCs) represent a heterogenous population of adult, fibroblast-like multi-potent cells.MSCs have drawn much attention during the last decade in the field of regenerative medici
Tumor-initiating cells(TICs) are a subpopulation of chemoresistant tumor cells that have been shown to cause tumor recurrence.Targeting and eliminating of TICs are therefore priorities for the develop