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Using oil-soluble initiator 2,2′-azobisisobutyronitrile(AIBN),poly(N-isopropylacrylamide-co-acrylic acid)(P(NIPAM-co-AA)),poly(styrene-co-acrylic acid)(P(St-co-AA)),poly(N-isopropylacrylamide)(PNIPAM))and poly(tert-butyl acrylate)(P(t-BA))micro-spheres with environmental responsive behavior were synthesized through emulsion polymerization,and the structure and properties of the obtained polymers were compared to those synthesized using water-soluble initiator,potassium persulfate(KPS).