Solidification of nanostructured lipid carrier onto pellets by fluid-bed coating:preparation, in vit

来源 :2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户:qw1567892
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  Previous studies have demonstrated that nanostructured lipid carrier (NLC) is a promismg system for poorly water-soluble drugs delivery with improved bioavailability.Conventional NLC,however,is mostly prepared in a liquid form,which has some disadvantages:drug expulsion during storage,thermodynamic instability and high water content of NLC suspension.Therefore,the conversion of the NLC suspension into a dry product is necessary.
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