The discovery of new drugs requires the development of improved animal models for drug testing.The classical animal models used for drugs discovery like mice,rats and monkeys,etc,have a limited application in drug pharmacological testing since various reasons,such as genetic relationship and economic costs.Therefore,its imperative to develop a novel animal model used for new drugs pharmacological testing.The Chinese tree shrew,one animal like squirrel,has a wide distribution in South Asia,Southeast Asia and Southwest China.In previous study,there had many reports about Chinese tree shrews possess many features valuable in animals used as experimental models in biomedical research.Now,it has been proved the Chinese tree shrew had a closer relationship with Human prompted the Chinese tree shrew maybe was a realistic candidate model.To assess the potential of the Chinese tree shrew for pharmacological testing,we performed drug target prediction and analysis on genomic and transcriptomic scales.Using our pipeline,3,482 proteins were predicted to be drug targets.Of these predicted targets,446 and 1,049 proteins with the highest rank and total scores,respectively,included homologs of targets for cancer chemotherapy,depression,age-related decline and cardiovascular disease.Based on comparative analyses,more than half of drug target proteins identified from the tree shrew genome were shown to be higher similarity to human targets than in the mouse.Target validation also demonstrated that the constitutive expression of the proteinase-activated receptors of tree shrew platelets is similar to that of human platelets but differs from that of mouse platelets.We developed an effective pipeline and search strategy for drug target prediction and the evaluation of model-based target identification for drug testing.This work provides useful information for future studies of the Chinese tree shrew as a source of novel targets for drug discovery research.