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5. Design,Synthesis and Evaluation of Orally Available Multi-Target-Directed Ligands for the Cognitive

Design,Synthesis and Evaluation of Orally Available Multi-Target-Directed Ligands for the Cognitive

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：ffxcat

【摘 要】

：

Microtubules are critical elements that are involved in a wide range of cellular processes,and thus,they have become an attractive target for many anticancer drugs.[1] A novel synthesized compound,12P

【作 者】

：

Jun Yan Yanqing Pang Ling Huang Xingshu Li 

【机 构】

：

School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China

【出 处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Microtubule anti-proliferative activity G2/M phase arrest apoptosis xenograft tu 

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　　Microtubules are critical elements that are involved in a wide range of cellular processes,and thus,they have become an attractive target for many anticancer drugs.[1] A novel synthesized compound,12P inhibits tubulin polymerization through binding to the colchicine-binding site of tubulin.

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