目的　探讨小剂量1 31 碘分次疗法治疗Graves病的疗效。方法　1 31 碘剂量降至常规计算用量的 1 2～ 2 3 ,1次顿服 ,3个月为 1疗程 ,进行疗效复查 ,如此重复分次治疗直至Graves病治愈。结果　治疗后 5年 ,3 2 7例患者中 ,痊愈3 0 9例 ,治愈率 94.5 %,未愈 14例 ,占 4.3 %,4例出现暂时性甲低 ,经治疗或观察半年后恢复。治愈总疗程 1～ 3个 ,时间3～ 9个月。痊愈病例中 ,1疗程服药治愈为 98人 ( 3 1.7%) ,2疗程治愈 182 ( 5 8.9%) ,3疗程治愈 2 9人 ( 9.4%) ,观察期间无一例出现甲亢复发或晚发甲低。结论　小剂量1 31 碘是治疗Graves病安全、有效的方法。 Objective To investigate the curative effect of small dose of 131 Iodine on Graves’ disease. Method 1 31 iodine dose reduced to the conventional calculation of the amount of 1 2 ~ 2 3, 1 times Dayton clothing, 3 months for a course of treatment, the effect of review, so repeat treatment until Graves disease cure. Results After 5 years of treatment, of the 327 patients, 399 cases were cured, the cure rate was 94.5%, and 14 cases were unhealed, accounting for 4.3%. Four cases had a temporary hypothyroidism and recovered after six months’ treatment or observation. Cure the total course of 1 to 3, time 3 to 9 months. Among the cured cases, 98 were cured during one course of treatment (37.7%), 182 (59.9%) after 2 courses and 29 (9.4%) after 3 courses of treatment. No recurrence of hyperthyroidism or late hypothyroidism . Conclusion Low-dose 131I is a safe and effective treatment for Graves disease.