Intoduction: The programmed death 1 (PD-1) protein is a critical regulator of T-cell activation and is also an important therapeutic target for autoimmune d
Objectives: Systemic sclerosis (SSc) is an autoimmune disease with unknown etiology.Studies have revealed epigenetic modification can contribute to suscepti
The apoptosis of glomerular mesangial cells (GMC) in rat Thy-1 nephritis (Thy-1N), a model of human mesangioproliferative glomerulonephritis (MsPGN), is acc
Objective: Loss of CD28 expression by CD8+ T cells occurs with age and during chronic inflammatory conditions.CD8+CD28-T cells are a heterogeneous cell subp