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【目的】探讨高压氧干预对丙戊酸钠(VPA)孤独症模型鼠学习记忆能力的影响,为高压氧治疗孤独症提供理论依据。【方法】通过Wistar大鼠怀孕第12.5天腹腔注射VPA的方法建立孤独症动物模型,采用Y型电迷宫测试评价高压氧干预对模型鼠学习记忆能力的影响。【结果】高压氧治疗孤独症模型组治疗后Y型电迷宫测试的尝试次数少于治疗前尝试次数(31.54±0.88vs 30.69±0.63,t=5.500,P=0.001),再现次数多于治疗前再现次数(2.85±0.69vs 3.38±0.65,t=2.214,P=0.047);常压高氧治疗孤独症模型组治疗后的尝试次数少于治疗前尝试次数(31.54±0.97vs 31.15±0.99,t=2.739,P=0.018),再现次数多于治疗前再现次数(2.69±0.48vs 3.00±0.58,t=2.309,P=0.040)。【结论】VPA孤独症动物模型建立成功,高压氧干预治疗可提高孤独症模型鼠的学习记忆能力。
【Objective】 To investigate the effect of hyperbaric oxygen on the learning and memory abilities of autistic rat model of VPA and provide a theoretical basis for the treatment of autism. 【Methods】 Autism animal models were established by intraperitoneal injection of VPA on day 12.5 of pregnancy in Wistar rats. The effects of hyperbaric oxygen therapy on learning and memory ability of model mice were evaluated by Y-type electric maze test. 【Results】 The number of attempts of Y-type electrical maze test after hyperbaric oxygen treatment in autism model group was less than that before treatment (31.54 ± 0.88 vs 30.69 ± 0.63, t = 5.500, P = 0.001) (2.85 ± 0.69 vs 3.38 ± 0.65, t = 2.214, P = 0.047). The number of attempts after treatment with autopental hyperoxia in autism model group was less than that before treatment (31.54 ± 0.97 vs 31.15 ± 0.99, t = 2.739, P = 0.018). The number of reappearances was more than that before treatment (2.69 ± 0.48vs 3.00 ± 0.58, t = 2.309, P = 0.040). 【Conclusion】 The animal models of VPA autism are established successfully. Hyperbaric oxygen therapy can improve learning and memory of autistic model rats.