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  5. The inhibitory effect of sertraline,a selective serotonin reuptake inhibitor on voltage-dependent K+

The inhibitory effect of sertraline,a selective serotonin reuptake inhibitor on voltage-dependent K+

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：a9249228
【摘 要】
：
We examined the effects of the selective serotonin reuptake inhibitor(SSRI)sertraline on voltage-dependent K+(Kv)channels in native coronary arterial smooth muscle cells using the voltage-clamp techni
【作 者】
：
Han Sol Kim Sung Eun Shin Won Sun Park 
【机 构】
：
Department of Physiology,Kangwon National University School of Medicine,Chuncheon,200-701,South Kore
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
Sertraline Coronary artery Voltage-dependent K+channel Serotonin reuptake inhibi 
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　　We examined the effects of the selective serotonin reuptake inhibitor(SSRI)sertraline on voltage-dependent K+(Kv)channels in native coronary arterial smooth muscle cells using the voltage-clamp technique.Sertraline decreased the Kv channel current in a dose-dependent manner,with an IC50 value of 0.18 μM and a slope value(Hill coefficient)of 0.61.
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