【摘 要】
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In the last few years we have constructed a series of human immunoagents directed to one of the most valuable tumor-associated antigens, the RTK ErbB2 (Her2
【机 构】
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Department of Structural and Functional Biology University of Naples Federico ⅡItaly
【出 处】
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BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
In the last few years we have constructed a series of human immunoagents directed to one of the most valuable tumor-associated antigens, the RTK ErbB2 (Her2/neu), over-expressed in many carcinomas, frequently in mammary carcinoma.We produced and characterized: Erbicin, a single-chain human anti-ErbB2 immunoagent, and two Erbicinderived immunoagents: Erb-hRNase, a fully human immunoRNase made up of Erbicin fused to a human RNase; Erb-hcAb, a fully human, compact (reduced size) antibody, in which two Erbicin molecules are fused to the Fc region of a human IgG1.
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