柠檬烯是广泛存在于植物中的环状单萜,可从葡萄、柠檬、桔子等水果的油中提取,常用作香料。美国FDA鉴定其为“通常认为是安全的”(GRAS)物质。该物质被认为具有抗癌作用,但其机制仍不清楚。为探讨柠檬烯与洛伐他汀(异戊二烯合成抑制剂)对癌症的联合治疗作用,研究者对9位不同类型癌症患者进行了药物干预实验。受试者每天服用2g柠檬烯、40mg洛伐他汀和100mg辅酶Q10。实 Limonene is a cyclic monoterpene found widely in plants and can be extracted from the oils of fruits such as grapes, lemons, oranges, etc., and is often used as a spice. The US FDA identifies it as a “generally considered safe” (GRAS) substance. The substance is considered to have anti-cancer effects, but its mechanism remains unclear. To investigate the combined effects of limonene and lovastatin (isoprene synthesis inhibitor) on cancer, the researchers conducted drug intervention experiments on nine different types of cancer patients. Subjects took 2 g limonene, 40 mg lovastatin and 100 mg coenzyme Q10 daily. real