Premature ovarian failure (POF) is a syndrome comprising amenorrhoea, sex steroid deficiency and elevated gonadotrophins occurring in women under the age of 40 years.It is estimated to affect 1% of women under the age of 40, 0.1% under 30 and 0.01% under 20.POF can be spontaneous or iatrogenic following surgical treatment for gynecological disorders or chemotherapy/pelvic irradiation for malignancy.Spontaneous POF is most commonly idiopathic, but many potential etiologies have been identified.Prospects for women with primary ovarian insufficiency who hope to become pregnant with their own oocytes are largely unknown.