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As we age, our ability to cope with a variety of stresses significantly decreases.One of the features of an ageing organism is the dramatic increase in the number of cells arrested in the G 1 phase, a process known as senescence.It is well established that the senescence phenotype leads to a change in the way cells respond to stress.However, the molecular mechanisms by which these cells cope and/or respond to a variety of environmental challenges remain unknown.In general, cells respond to stress by engaging a variety of mechanisms; one of them is the assembly of cytoplasmic foci known as stress granules (SGs).These entities are considered as part of the survival pathways that are activated at the beginning of any stress to protect key cellular elements which allow a quick recovery if the stress is rapidly removed.