【摘 要】
：
This study investigated the association of 6 sortilin-related receptor l ( SORLI ) variants with cognitive impairment.SORLI SNPs 8.9.10,13.19 and 23
【机 构】
：
St.Luke'sMedicalCenter
【出 处】
：
第十五届亚太分子生物学网络组织年会
论文部分内容阅读
This study investigated the association of 6 sortilin-related receptor l ( SORLI ) variants with cognitive impairment.SORLI SNPs 8.9.10,13.19 and 23 were genotyped in 484 Filipinos,including 100 Alzheimers disease (AD) cases.109 mild cognitive impairment (MCI) cases.257 with no dementia and 18 with other cases of cognitive impairment,using TaqMan? SNP Genotyping Assays.Cognitive impairment (CI).which includes AD,MCI and other cognitive impairment cases,was associated with SNP 23 (p = 0.041). None of the SORLI variants was associated with AD.
其他文献
阿尔茨海默病 (Alzheimer’s disease,AD)的主要病理学标志是大脑神经元外部出现以Aβ (amyloid-β) 为核心成分的老年斑.Aβ 是由Aβ 前体蛋白(amyloid-β precursor protei
Iron accumulation is considered to be involved in the pathogenesis of Parkinson’s disease (PD).The aim of present study is to investigate the mechanism involve
Dysregulation of iron homeostasis is involved in the pathological process of Alzheimer’s disease (AD).We have recently reported that divalent metal transporter
Objective: To study the mechanism of overexpression of mitochondrial ferritin(MtFt) for inhibiting euroblastoma cells proliferation.Method: electedtFt-SY5Y cell
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression levels of the frataxin gene (FXN) due to expansion of
Graphene oxide (GO) displays promising properties for biomedical applications including drug delivery and cancer therapeutics.However,GO exposure also raises sa
Cellular zinc influx and efflux are maintained by two major transporter families,ZIP (SLC39A) and ZnT (SLC30A or CDF).The functions for ZIP11/SLC39A11 remain un
Iron is an essential element but possesses potential toxicity for aerobic lives.Ferritin,a large protein complex with high capacity of iron incorporation,can se
目的:(1) 发现并证实睾酮合成相关新的锌转运体——ZnT8.(2) 阐明ZnT8 参与睾酮合成的机制.方法:应用免疫荧光双标和激光共聚焦扫描显微镜及Western Blot 技术获取ZnT8 在小
Lycopene is generally consumed and known for its antioxidant activities.In this study,we hypothesized that lycopene can prevent iron-mediated oxidative stress,p