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Many studies have reported the association between the CARD8 gene polymorphism rs2043211 and the susceptibility to Crohns disease (CD), but the results have remained quite contradictory.Therefore, the aim of the meta-analysis was to explore whether the CARD8 rs2043211 polymorphism has an effect on CD risk.We performed a systematic literature search for related articles published up to July 2014 in multiple databases.