Apart from the heavy metals, the group of persistent organic pollutants (POPs) includes manycompounds regarded as major environmental problems. Polychlorinated biphenyls are one of thePOPs classic families, and polybrominated Biphenyl ethers are one of the emerging POPs.Polychlorinated biphenyls (PCBs) were commercially produced as complex mixtures for a varietyof uses, including dielectric fluids in capacitors and transformers, heat transfer fluids,hydraulicfluids, lubricating and cutting oils, and as additives in pesticides, paints, copying paper, carbonlesscopy paper, adhesives, sealants and plastics. Polybrominated Biphenyl ethers (PBDEs) constitute animportant group of brominated flame retardants. The compounds are mostly found in ready-madeplastic products. PBDEs are used in large quantities world wide and are persistent in theenvironment. These compounds and their harmful effects on the environment and human have beenextensively reviewed. Apart from the wide uses, PCBs and PBDEs act harmful effects. PCBs couldact "dioxin-like" toxic activity and may induce neuroevelopmental effect to cause developmentaleff}ts in humans. Similarly to PCBs, PBDEs are structurally similarly to polychlorinateddibenzo-p-dioxins (PCDD), both of which are known be toxic. Therefore, PBDEs might act"dioxin-like" toxic activity. PBDEs also could hinder the thyroid hormones system. And recentstudies indicate that PBDEs also have neuroevelopmental effects. Moreover, for the highlipophilicity and persistence, PCBs and PBDEs are known to possess high bioaccumulation andbiomagnification capacities, which mean that the concentration increases through a food chain. Forhumans, the major route of exposure to PCBs and PBDEs is via food contamination, so humanpopulations might suffer high risks of PCBs and PBDEs from daily foods. Develop the GC/MSMS analysis methods for PBDEs and PCBs, and the precision, nicety and limitof quantification have achieved the international level. To our best knowledge, it firstly reported the contamination levels and human exposure levels ofPBDEs, which people pay more attention to,in food products in Yangtze River Delta. And also it reported the contamination and human exposure levels of PCBs in food products. Based on the determination of PBDEs, the mean of total PBDEs in foods is 182 pg/g ww. It is muchlower than other countries. For the specified foods, the concentration ranks as Pork sausage>Duck>Catfish>Mandarin fish>Parabramis pekinensis>Snakehead>Weever > Pork > Crucian>Beef>Chicken>Shrimp, and the mean of total PBDEs are 356, 298, 273, 267, 244, 189, 156, 111, 96,76, 64 and 51 pg/g ww. In all samples, the dominant BDE congener is BDE-47, following BDE-100,BDE-28, BDE-99, BDE-154, BDE-153, BDE-66, BDE-71, BDE-138 and BDE-183. TheTetra-BDEs are the dominant BDE congeners in the food products, and it ranges from 47.8%-80.4%of the overall PBDEs, following Penta-BDEs ranging from 5.6%-22.6%, Hexa-BDEs ranging from8.0%-20.8%, Tri-BDEs ranging from 3.8%-14.3% and Hepta-BDEs ranging from 0.1%-0.8%. The results of this study found that the mean of total PCBs in foods is 16.6ng/g ww and meatproducts have the highest overall PCBs levels (mean of 17.92ng/g ww, range 8.50-37.90ng/g ww),followed by fish products (mean of 15.69ng/g ww, range 1.61-26.30ng/g ww). Based on this study,the means of total PCBs in food samples range from 1.61ng/g ww (for shrimp) to 37.90ng/g ww (forpork sausages). The rank of concentration of total PCBs in food products is: CB-81>CB-170+CB-180>CB-138>CB-153>CB-114>CB-28>CB-105>CB-118>CB-101> CB-187.Penta-CBs are the predominant component among all homologues, and a consistent profile waspresent in all samples, and it ranges from 22%-32% of the overall PCBs, following Hexa-CBsranging from 19%-37%, Te宜ra-CBs ranging from 14%-26%, Hepta-CBs ranging from 14%-21%andTri-CBs ranging from 3%-13%. Comparison PCBs with PBDEs in food products, PCBs have the much higher level than PBDEs.The amount of PCBs and PBDEs is highly correlated within each food product. The contaminationlevels of PBDEs and PCBs in food products would suggest that PCBs, PBDEs might be distributedthroughout the food products and other environmental matrices. The total human exposure level through food products at Nanjing is 164.64pg/kg body weight.Compare with the results of other countries, the total exposure level in Nanjing is lower than the other countries. Also, the total human exposure level through food products at Nanjing is14.57ng/kg body weight.