论文部分内容阅读
目的:观察麝香保心丸治疗冠心病的临床疗效及对血管内皮功能的影响。方法:使用随机数字表法将90例冠心病患者分为对照组和观察组(n=45),对照组采用冠心病常规治疗措施,观察组在常规治疗的基础上加用麝香保心丸,比较两组患者的治疗效果及血管内皮功能指标变化。结果:观察组治疗后FMD及血清NO、NOS、SOD、6-Keto-PGF-1α水平显著高于对照组,血清ET-1、TXA2水平均显著低于对照组(P<0.05);观察组总有效率显著高于对照组(P<0.05)。结论:麝香保心丸能通过纠正TXA2/PGI2、ET/NO失衡,对血管内皮功能发挥正向调节作用,改善血管内皮功能,提高冠心病治疗效果。
Objective: To observe the clinical efficacy of “Shexiang Baoxin Pill” in treating coronary heart disease and its effect on vascular endothelial function. Methods: Ninety patients with coronary heart disease were divided into control group and observation group (n = 45) by random number table method. The control group was treated by conventional treatment of coronary heart disease. The observation group was treated with “Shexiang Baoxin Pill” The therapeutic effects and the changes of endothelial function were compared between the two groups. Results: The levels of NO, NOS, SOD and 6-Keto-PGF-1α in the observation group were significantly higher than those in the control group, the levels of ET-1 and TXA2 in the observation group were significantly lower than those in the control group (P <0.05) The total effective rate was significantly higher than the control group (P <0.05). Conclusion: Shexiangbaoxin Pill can correct the imbalance of TXA2 / PGI2 and ET / NO and play a positive role in the function of vascular endothelial cells, improve endothelial function and improve the therapeutic effect of coronary heart disease.