论文部分内容阅读
选择Ｂｃｌ－２蛋白质作为标记蛋白，着重观察移植肾组织结构和肾功能正常时，以及发生急性排异时其肾组织浸润细胞中该蛋白染色阳性细胞的变化。结果表明，未发生ＡＣＲ的肾组织结构正常的标本中，Ｂｃｌ－２阳性细胞数仅在术后３个月时高于术前水平；移植肾发生ＡＣＲ时，Ｂｃｌ－２阳性细胞增加明显，是未发生ＡＣＲ肾组织的７．６９倍。对移植肾间质Ｂｃｌ－２阳性细胞数与其浸润的ＣＤ４或ＣＤ８细胞数回归相关性分析发现，移植肾总体标本中ＣＤ４或ＣＤ８细胞数与间质中Ｂｃｌ－２阳性细胞数量正相关。
Bcl-2 protein was selected as the marker protein, and the changes of the positive staining cells in renal infiltrating cells were observed when the renal tissue structure and renal function were normal, and when acute rejection occurred. The results showed that the number of Bcl-2 positive cells was higher than preoperative levels at 3 months postoperatively in ACR-free normal renal tissues. The Bcl-2 positive cells increased significantly in ACR of renal allografts 7.69 times of ACR kidney tissue did not occur. Correlation analysis between the number of Bcl-2 positive cells and the number of infiltrating CD4 or CD8 cells in the transplanted renal interstitium showed that there was a positive correlation between the number of CD4 or CD8 cells and the number of Bcl-2 positive cells in the interstitium.