诱导多能干细胞(iPSCs)是由多种体细胞重编程而获得的,具有与胚胎干细胞(ESCs)相似的特性,能自我更新、无限增殖和多向分化的特性。但目前iPSCs向心肌细胞自发分化的效率非常低。如何才能有效地诱导iPSCs向心肌细胞的定向分化,对深入认识心肌细胞发生和发育的机制及实现其在药物筛选和心血管疾病治疗中的作用均具有非常重要的意义。本文重点对近年来iPSCs向心肌细胞分化策略的研究进展进行综述。 Induced pluripotent stem cells (iPSCs) are reprogrammed from a variety of somatic cells with similar properties as embryonic stem cells (ESCs), self-renewing, immortal proliferation and multidirectional differentiation. However, the current iPSCs to the cardiomyocyte spontaneous differentiation efficiency is very low. How to effectively induce directional differentiation of iPSCs into cardiomyocytes is of great significance for understanding the mechanism of cardiomyocyte occurrence and development and for realizing its role in drug screening and treatment of cardiovascular diseases. This review focuses on the recent advances in iPSCs differentiation into cardiomyocytes.