从采样方式、采样原理、适用性、发展趋势、样品浓度与机体整体浓度的关联性角度比较微透析采样技术与经典药动学采样技术的异同,探讨微透析技术进行药动学研究的适用性,根据采样对象性质,深入思考其样品数据处理的特殊性,提出并总结关于微透析样品数据的校正方法以提升微透析技术进行药动学研究的稳健性及结果可靠性。 The similarities and differences between microdialysis sampling techniques and classical pharmacokinetic sampling techniques were compared in terms of sampling method, sampling principle, applicability, development trend, the correlation between sample concentration and total body concentration, and the applicability of microdialysis technology to pharmacokinetic studies , According to the nature of the sample object, we deeply think about the particularity of the sample data processing and propose and summarize the calibration method of the microdialysis sample data so as to improve the robustness and reliability of the microdialysis technology for the pharmacokinetic study.