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目的:探讨钙粘素及其胞内结合蛋白在膀胱移行细胞癌中的表达及其在膀胱癌浸润转移和预后中的价值。方法:免疫组化SP法。结果:膀胱癌组织中,ECD、α-、β-、β-Catenin表达减弱,分别为58％(29/50)、56％(28/50)、68％(34/50)及52％(26/50),不同分级间有非常显著的差异;浸润性膀胱癌中每种分子的表达均显著低于浅表性膀胱癌;生存期高于5年者,ECD、α-、γ-Catenin表达显著高于生存期低于5年者。结论:膀胱癌中ECD、α-、β-、γ-Catenin表达的显著降低,其低表达与膀胱癌的高分级及浸润性有明显关系,检测这些分子对膀胱癌患者的预后判断有一定的价值。
Objective: To investigate the expression of cadherin and its intracellular binding protein in bladder transitional cell carcinoma and its significance in invasion, metastasis and prognosis of bladder cancer. Methods: Immunohistochemical SP method. Results: The expressions of ECD, α-, β- and β-Catenin in bladder cancer tissues were significantly lower than those in normal bladder tissues (58%, 28/50, 68%, and 52% 26/50). There were significant differences among different grades. The expression of each molecule in invasive bladder cancer was significantly lower than that in superficial bladder cancer. The survival rates of ECD, α-, γ-Catenin The expression was significantly higher than the survival of less than 5 years. CONCLUSIONS: The expression of ECD, α-, β-, γ-Catenin in bladder cancer is significantly lower than that in bladder cancer. The low expression of ECD, α-, β- and γ-Catenin is closely related to the high grade and invasiveness of bladder cancer. The detection of these molecules in bladder cancer patients has a certain prognosis value.