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目的:探讨PTEN蛋白在外阴鳞癌的发生、发展及估计预后中的作用。方法:采用免疫组化S-P法检测PTEN在正常外阴表皮、外阴上皮内非瘤样病变、外阴上皮内瘤变和外阴鳞状细胞癌的表达。结果:从外阴鳞状细胞癌→外阴上皮内瘤变→外阴非瘤样病变→正常外阴表皮,PTEN蛋白表达率逐渐升高。VSCC组与正常外阴表皮、外阴非瘤样病变、外阴上皮内瘤变组比较,PTEN蛋白的表达率有显著性差异(P<0.05)。PTEN蛋白表达阳性组患者生存率明显高于阴性组(P<0.05)。PTEN蛋白的表达虽存在于各临床分期、组织学分级及淋巴结转移中,但在各组之间的差异无显著性(P>0.05)。结论:PTEN蛋白表达可能是一个早期事件,在外阴癌的发生、发展过程中起重要作用,可作为判断预后的指标之一。
Objective: To investigate the role of PTEN in the occurrence, development and prognosis of vulvar squamous cell carcinoma. Methods: The expression of PTEN in normal vulvar epidermis, vulvar intraepithelial neoplasia, vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma was detected by immunohistochemical S-P method. Results: From the vulvar squamous cell carcinoma → vulvar intraepithelial neoplasia → vulvar non-neoplastic lesions → normal vulvar epidermis, PTEN protein expression increased gradually. There was a significant difference in the expression of PTEN protein between VSCC group and normal vulvar epidermis, vulvar non-tumorous lesion and vulvar intraepithelial neoplasia group (P <0.05). The survival rate of PTEN positive group was significantly higher than that of negative group (P <0.05). Although PTEN protein expression exists in all clinical stages, histological grade and lymph node metastasis, there was no significant difference between the groups (P> 0.05). Conclusion: PTEN protein expression may be an early event that plays an important role in the occurrence and development of vulvar cancer and may be used as one of the prognostic indicators.