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目的:观察青紫合剂治疗儿童过敏性紫癜的临床疗效及机理。方法:确诊过敏性紫癜患儿150例,随机分为观察组和对照组各75例。对照组采用常规治疗,观察组在常规治疗基础上加用青紫合剂治疗,比较两组患儿的临床疗效(包括皮疹消退时间、消化道症状缓解时间、关节症状缓解时间)、凝血功能、血沉、细胞免疫恢复时间。结果:观察组患儿总临床疗效好于对照组,差异有统计学意义(P<0.05);皮疹消退时间、消化道症状缓解时间、关节症状缓解时间均短于对照组,差异有统计学意义(P<0.001)。同时观察组患儿的凝血功能、血沉、细胞免疫恢复时间均短于对照组,差异有统计学意义(P<0.05)。结论:在常规治疗基础上联合应用青紫合剂治疗儿童过敏性紫癜患儿疗效可靠,可明显改善临床症状,其作用机理可能为改善高凝血状态,抑制炎性反应,调节细胞免疫,值得进一步观察研究。
Objective: To observe the curative effect and mechanism of Qing Zu Mixture in treating children’s Henoch-Schonlein purpura. Methods: 150 children with Henoch-Schonlein purpura were randomly divided into observation group and control group with 75 cases each. The control group was treated with routine treatment. The observation group was treated with Qing Zi Heji on the basis of routine treatment. The clinical efficacy (including the time of rash subsidence, the relief time of gastrointestinal symptoms, the time of relieving joint symptoms), coagulation function, erythrocyte sedimentation rate, Cellular immune recovery time. Results: The overall clinical efficacy of the observation group was better than that of the control group (P <0.05). The regression of rash, the time of digestive tract symptom relief and the relief of joint symptoms were shorter than those of the control group (P <0.001). At the same time, the coagulation function, erythrocyte sedimentation rate, and cellular immune recovery time in the observation group were shorter than those in the control group, with statistical significance (P <0.05). Conclusion: The combination of Qing Zu Mixture on the basis of routine treatment of children with Henoch-Schonlein purpura treatment of children with reliable and can significantly improve clinical symptoms, its mechanism of action may be to improve the state of high blood coagulation, inhibition of inflammatory response, regulation of cellular immunity, it is worth further observation .