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目的探讨白细胞分化抗原93(CD93)对冠状动脉病变程度的预测价值,为冠心病的诊断提供新的预测依据。方法选取2010年1月至2012年6月在潍坊市心脏病医院行选择性冠状动脉造影检查的498例患者为研究对象,男性291例,女性207例,平均年龄(55.0±11.8)岁。根据冠状动脉评分(Gensini)系统结果,将患者分为4组:正常组(0~4分)219例,轻度病变组(5~16分)132例,中度病变组(17~32分)93例,重度病变组(33~分)54例。用自动生化仪和相应试剂检测患者的血清CD93水平及甘油三脂(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A和载脂蛋白B水平。用SPSS 18.0进行统计学分析,多组间比较用方差分析,进一步两两比较用q检验。CD93水平与冠状动脉病变狭窄程度的关系采用直线相关及逐步回归进行分析。结果不同冠状动脉病变程度组CD93水平的差异有统计学意义(F=60.128,P<0.01),随着病变程度的加重,CD93水平逐渐升高,各组间比较,差异均有统计学意义(P<0.05)。Pearson相关分析结果表明,CD93与Gensini评分值呈直线正相关,在控制其他变量(如年龄、性别及其他血脂指标等)后,偏相关系数为0.382,有统计学意义(P<0.01)。逐步回归分析进一步证明,CD93能够独立预测冠状动脉病变的严重程度(χ~2=42.13,P<0.01)。结论 CD93水平能够独立预测冠状动脉粥样硬化病变程度,可为冠心病的诊断提供参考。
Objective To investigate the predictive value of leukocyte differentiation antigen 93 (CD93) on the degree of coronary artery disease and provide a new prediction basis for the diagnosis of coronary heart disease. Methods From January 2010 to June 2012, 498 patients undergoing selective coronary angiography at the Weifang Cardiology Hospital were selected as the study subjects. There were 291 males and 207 females, with an average age of 55.0 ± 11.8 years. According to the result of Gensini system, the patients were divided into 4 groups: 219 in normal group (0-4), 132 in mild group (5-16), moderate in group (17-32) ) 93 cases, severe lesions group (33 points) 54 cases. Serum level of CD93, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) Lipoprotein A and Apolipoprotein B levels. Statistical analysis was performed with SPSS 18.0, and variance analysis was used to compare multiple groups. Further comparison was performed with q test. The relationship between the level of CD93 and the degree of coronary artery stenosis was analyzed by linear correlation and stepwise regression. Results The level of CD93 in different degree of coronary artery disease was significantly different (F = 60.128, P <0.01). The level of CD93 increased with the severity of coronary artery disease. The differences among the three groups were statistically significant ( P <0.05). Pearson correlation analysis showed that there was a linear positive correlation between CD93 and Gensini scores. The partial correlation coefficient was 0.382 (P <0.01) after controlling for other variables (such as age, sex and other blood lipids). Stepwise regression analysis further confirmed that CD93 could independently predict the severity of coronary artery disease (χ ~ 2 = 42.13, P <0.01). Conclusion The level of CD93 can independently predict the severity of coronary atherosclerosis and provide a reference for the diagnosis of coronary heart disease.