目的 :建立HPLC法测定小儿速效感冒冲剂中对乙酰氨基酚 ;方法 :用DescriptionC18(2 5 0mm× 4 .6mm ,5 μm)色谱柱 ;流动相水 甲醇 (6 5∶35 ) ;流速 0 .8ml·min-1,检测波长 2 4 9nm ;结果 :线性范围 0 .10 4～ 0 .5 2 0mg·ml-1,r =0 .9999;平均加样回收率为 98.80 % ,RSD =1.13% (n =5 )。结论 :本法简便、准确、灵敏度高、重现性好 ,为提高小儿速效感冒冲剂质量标准提供了一个可借鉴的方法。 OBJECTIVE: To establish a HPLC method for the determination of paracetamol in children’s quick-effect cold-drizzling granule.METHODS: The sample was eluted with a Description C18 (250 mm × 4.6 mm, 5 μm) column and the mobile phase was water methanol (6:35) · Min-1, detection wavelength of 2 49nm; Results: The linear range was 0.10 4 ~ 0.520 mg · ml -1, r = 0.9999; The average recovery was 98.80%, RSD = 1.13% n = 5). Conclusion: This method is simple, accurate, sensitive and reproducible, which can provide a reference for improving the quality standard of instant cold granules in children.