在实施含大剂量 DDP的肿瘤化疗方案过程中，我们采用不完全水化方案，减少病人化疗中的输液量。观察 46周期含大剂量 DDP的联合化疗不同水化方案的肾毒性反应，总结如下。 1 临床资料 在含大剂量 DDP的 46周期化疗中，男 25周期，女 21周期，年龄范围 36～ 72岁，中位年龄 59. During the implementation of a chemotherapy regimen for tumors containing large doses of DDP, we used an incomplete hydration protocol to reduce the amount of fluid in patients undergoing chemotherapy. Observation of the 46-cycle nephrotoxicity response to different hydration regimens in combination with high-dose DDP was summarized below. 1 clinical data in 46 cycles of chemotherapy with high doses of DDP, male 25 cycles, female 21 cycles, age range 36 to 72 years, median age 59.