论文部分内容阅读
报告２１例角化棘皮瘤。临床表现均为单发性，开始为一小的丘疹，迅速增大为半球状隆起于皮面的结节或肿块，中央呈火山口样凹陷，其内充满角质。组织病理变化：早期损害表皮凹陷如火山口样，充满角质物。底部表皮增生，有些病例含有不典型细胞、核丝分裂及角珠。充分发展的损害，火山口样凹陷继续扩大，两侧表皮如拱璧状。２０例的瘤底部较平坦，界限清楚，但另１例瘤的底部个别上皮细胞侵入横纹肌束之中。真皮内可见致密的嗜中性白细胞及嗜酸性白细胞浸润。超微结构显示增生的上皮细胞表面有许多不规则波浪状的微绒毛，桥粒数目增多，张力微丝减少，有相当多的胞质内桥粒
21 cases of keratoacanthoma were reported. The clinical manifestations were solitary, starting with a small papule, rapidly increasing to a hemispherical nodule or mass that bulges to the surface of the skin, and a crater-like depression in the center, which is filled with keratin. Histopathological changes: early damage to the epidermis, such as crater-like, full of keratin. At the bottom of the epidermis, some cases contain atypical cells, nuclear fission and corner beads. With fully developed damage, the crater-like depression continues to expand, with epidermis on both sides. The bottom of the tumor was flat and well defined in 20 cases, but the other individual epithelium of the tumor invaded into the striated muscle bundle. Dense neutrophils and eosinophils are seen in the dermis. The ultrastructure shows that there are many irregular wavy microvilli on the surface of proliferating epithelial cells, the number of desmosomes increases, the tension microfilaments decrease, and there is a considerable amount of cytoplasmic desmosomes.