目的探讨白术醇提物的抗炎镇痛活性。方法采用热板法测定白术不同剂量组小鼠的痛阈值,腹腔注射0.6%醋酸刺激致痛模型(扭体法)观察白术3个不同剂量的镇痛作用;采用二甲苯致小鼠耳廓肿胀实验和角叉菜胶致大鼠足肿胀实验观察3个不同剂量白术的抗炎作用。结果高、中剂量的白术醇提物可显著增加小鼠的热板痛阈值(P<0.01),减少腹腔注射醋酸引起的小鼠扭体反应次数(P<0.01),而白术低剂量组不能有效的提高小鼠的痛阈值和减少扭体反应次数。在抗炎试验中,高、中剂量的白术醇提物可显著抑制小鼠耳廓肿胀度(P<0.01),而低剂量组对小鼠耳廓肿胀抑制效果不明显;高剂量组在2 h后能显著抑制大鼠足跖肿胀,中剂量组(除6 h时间点)与白术醇提物低剂量组(除3 h时间点)在药后0.5~6 h之间与模型组比较均无显著性差异。结论白术醇提物具有较好的抗炎、镇痛作用,并呈现一定的剂量依赖性。 Objective To investigate the anti-inflammatory and analgesic activity of alcohol extract of Baizhu. Methods The pain threshold values ​​of different doses of Atractylodes macrocephalae were determined by hot plate method. The analgesic effects of Atractylodes macrocephalae at different doses were observed by intraperitoneal injection of 0.6% acetic acid stimulating pain model (writhing method) Experimental and carrageenan-induced rat foot swelling experiment observed anti-inflammatory effects of three different doses of Atractylodes. Results High and medium doses of Atractylodes macrocephalae extract could significantly increase the threshold of thermochromic pain in mice (P <0.01), reduce the number of writhing reactions induced by intraperitoneal injection of acetic acid (P <0.01) Effectively increase the pain threshold in mice and reduce the number of writhing reactions. In the anti-inflammatory test, high and medium doses of Atractylodes macrocephala alcohol extract can significantly inhibit the auricle swelling of mice (P <0.01), while the low dose group had no obvious effect on the auricle swelling of mice; high dose group h significantly inhibited rat paw edema. Compared with the model group, the middle dose group (except for 6 h time point) and the low dose Baicalutang extract group (except 3 h time point) No significant difference. Conclusion Atractylodes alcohol extract has good anti-inflammatory and analgesic effects and shows a dose-dependent manner.