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本文考察了渗透促进剂Azone（AZ）、油酸（OA）、丙二醇（PG）等和离子导入法（Ag／AgCl或Pt电极，电流密度0.19mA／cm2，频率2000Hz，占／空比1：1）对褪黑激素（MT）皮肤渗透性的影响。MT能透过小鼠全皮，其稳态流量和渗透系数分别为1622×10-3μg／cm2．s和0.8888×10-6cm／s：100％AZ、5％AZ／PG和10％OA／PG处理皮肤后，MT的稳态流量分别是未处理组的7.61、7.03和2.98倍；MT作为非离子性药物，离子导入对其也有促渗作用，离子导入处理组的稳态流量是未处理组的2.19倍。结果表明渗透促进剂（AZ、OA）、离子导入法均能增加MT的经皮渗透。
In this paper, the effects of azone (AZ), oleic acid (OA), propylene glycol (PG) and iontophoresis (Ag / AgCl or Pt electrode) on the current density of 0.19mA / cm2, frequency of 2000Hz, 1) on the skin permeability of melatonin (MT). MT through the whole skin of mice, the steady-state flow and permeability coefficients were 1622 × 10-3μg / cm2. The steady-state flux of MT was 7.61, 7.03 and 2.98 times that of the untreated group after treatment of the skin with 0.8888 × 10-6cm / s and 0.8888 × 10-6cm / s respectively: 5% AZ / PG and 10% OA / Ionic drugs, iontophoresis also promote its role in the steady-state flow of iontophoresis treatment group was 2.19 times the untreated group. The results showed that the penetration enhancers (AZ, OA), iontophoresis can increase the MT transdermal penetration.